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Chih-Chuang Liaw, Professor and Chairman


廖志中 教授 兼系主任
Chih-Chuang Liaw, Professor 
and Chairman

Ph.D.(2004) 高雄醫藥大學
Ph.D.(2004) Kaohsiung Medical University

*海洋生物技術暨資源學系 教授(2016.06起)
 Associate Professor,2012.8
 Assistant Professor 2010.8
 Assistant Professor of China Medical University 2006.02


Natural Products Chemistry


A. Journal Papers: 
1. Yaun-Chao Huang, Tsong-Long Hwang, Yu-Liang Yang, Shih-Hsiung Wu, Mei-Hua Hsu, Jih-Pyang Wang, Sheng-Chih Chen, Li-Jiau Huang, and Chih-Chuang Liaw*, ‘Acetogenin and Prenylated Flavonoids from Helminthostachys zeylanica with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils’, Planta Med. 2010, 76, 447-453. (Impact factor 2.154, Plant Sciences, 56/190=29.5%, * correspondence)
2. Chih-Chuang Liaw, Tung-Ying Wu, Fang-Rong Chang, Yang-Chang Wu, ‘Historic Perspectives of Annonaceous Acetogenins. From Chemical Bench to Preclinical Trials’, Planta Med., 2010, 76, 1390-1404. (Impact factor 2.154, Plant Sciences, 56/190=29.5%)
3. Chih-Chuang Liaw,* Wen-Ying Liao, Chien-Sheng Chen, Yang-Chang Wu, Shu-Chuan Jao, Chia-Ning Shen*, and Shih-Hsiung Wu,* “Calcium-chelating Capability of Tetrahydrofuranic Moieties Modulates Cytotoxicity of Annonaceous Acetogenins” Angew. Chem. Int. Ed. 2011, 50, 7885–7891. (Impact factor 13.455, Chemistry, Multidisciplinary, 7/154=4.5%, * correspondence)
4. Chih-Chuang Liaw; Jia-Lin Chang;* Shou-Fong Chen; Jhih-Hong Huang; Jyun-Fu Sie; Yung-Yi Cheng, “Simulations of circular dichroism spectra of a pair of diterpene enantiomers by time-dependent density functional theory” Chem. Phys. Lett. 2011, 517, 51-54. (Impact factor 2.337, Physics, Atomic, Molecular & Chemical, 12/33=36.4%)
5. Wen-Ying Liao, Chia-Ning Shen, Li-Hua Lin, Yu-Liang Yang, Hsin-Ying Han, Jing-Wei Chen, Sheng-Chu Kuo, Shih-Hsiung Wu, Chih-Chuang Liaw,* “Asperjinone, A Nor-Neolignan, and Terrein, A Suppressor of ABCG2-expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus”, J. Nat. Prod. 2012, 75, 630-635 (IF: 3.789, Plant Sciences, 23/200=11.5%)
6. Shwu-Li Wu, Jui-Hsin Su, Chiung-Yao Huang, Chi-Jen Tai, Ping-Jyun Sung, Chih-Chuang Liaw, Jyh-Horng Sheu,* “Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex”, Mar. Drugs, 2012, 10, 1203-1211. (IF: 2.853, Chemistry, Medicinal, 22/59=37.3%)
7. David J. Gonzalez, Yuquan Xu, Yu-Liang Yang, Eduardo Esquenazi, Wei-Ting Liu, Anna Edlund, Tram Duong, Liangcheng Du, István Molnár, William H. Gerwick, Paul R. Jensen, Michael Fischbach, Chih-Chuang Liaw, Paul Straight, Jack E. Dixon, Victor Nizet, Pieter C. Dorrestein,* “Observing the Invisible through Imaging Mass Spectrometry, a Window into the Metabolic Exchange Patterns of Microbes”, J. Proteomics, 2012, 75, 5069-5076. (IF: 3.888, Biochemical Research Methods, 16/79=20.2%).
8. Hui-Yu Fang,# Chih-Chuang Liaw,# Chih-Hua Chao, Zhi-Hong Wen, Yang-Chang Wu, Chi-Hsin Hsu, Chang-Feng Dai, and Jyh-Horng Sheu, “Bioactive Pregnane–type Steroids from the Soft Coral Scleronephthya gracillimum”, Tetrahedron 2012, 68, 9694-9700. (IF: 2.641, Chemistry, Organic, 17/57=29.8%, # equal contribution)
9. Hui-Chi Huang, Chih-Chuang Liaw, Hsin-Ling Yang, You-Cheng Hseu, Hsiou-Ting Kuo, Yao-Ching Tsai, Shih-Chang Chien, Sakae Amagaya, Yu-Chang Chen, Yueh-Hsiung Kuo. “Lanostane triterpenoids and sterols from Antrodia camphorate.Phytochemistry 2012, 84, 177–183. (IF: 2.547, Plant Sciences, 53/200=26.5%)
10. Yung-Yi Cheng, Jai-Sing Yang, Shih-Chang Tsai, Chih-Chuang Liaw, Jing-Gung Chung, Li-Jiau Huang, Kuo-Hsiung Lee, Chi-Cheng Lu, Hsi-Cheng Chien, Minoru Tsuzuki, Sheng-Chu Kuo, “The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.” Oncology Reports. 2012, 28, 1482-1490. (IF: 2.301, Oncology, 138/211=65.4%)

執行之研究計劃(research projects):
1. The study on the bioactive substances of Avicenia marina, Sesuvium portulacastrum, and Pittosporum moluccanum in Pingtung mangrove swamp, supported by the grant from National Science Council (屏東紅樹林區植物-海茄苳、海馬齒、蘭嶼海桐-之活性成分研究,NSC 100-2320-B-110 -004).
2. The study on the antibiotic and anti-inflammatory secondary metabolites from marine micro-organisms, supported by the grant from National Science Council (自海洋微生物獲取具抗生活性之天然產物,NSC 101-2320-B-110 -001).
1. The study on the secondary metabolites from marine microorganisms and their modified analogues to inhibit opportunistic pathogens, supported by the grant from National Science Council (研究海洋微生物二次代謝物及其衍生物在抑制伺機性病菌之作用,NSC 102-2320-B-110 -002).
4. The study on the secondary metabolites from marine microbes as marine ligands to complexe with trace metals, supported by the grant from National Science Council (海洋微生物所產之二次代謝物做為海洋配體對微量金屬之螯合作用研究,NSC 102-2611-M-110 -008).
5. The study on establishing the strategy on rapidly searching novel bioactive natural products from marine microbes by molecular networking the grant from Ministry of Science and Technology (利用質譜分子網絡等工具建立快速尋找新型海洋微生物活性天然產物之策略,MOST 103-2628-B-110-001-MY3)
6. The study on elucidating the relationship between trace metal and molecular networking, supported by the grant from Ministry of Science and Technology (以海洋微生物代謝物分子網路建立其海洋配體與海洋微量金屬之關係,MOST 103-2611-M-110-006)




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