主題: 抗結核藥物貝達喹啉在細胞和動物實驗中抑制登革病毒及其相關功能The anti-tuberculosis drug Bedaquiline inhibits DENV and its related functions in cell and animal experiments

學生:黃仕齊

指導教授:李景欽教授

Background

Dengue virus (DENV) causes dengue fever. In our preliminary study, we identified a drug used to treat active tuberculosis (Compound B). In cell-based experiments, Compound B was found to inhibit viral replication and reduce the mortality rate of DENV-infected mice in animal models. Previous studies have shown that Compound B binds to the Fo subunit of F-type FoF1 ATP synthase (ATPase), inhibiting ATP synthesis and energy production, thereby suppressing viral replication. Based on these findings, this study aims to investigate whether Compound B exerts its antiviral effects by inhibiting ATP synthesis, explore its detailed mechanisms, and examine its activity in suppressing inflammation.